Role Of Intravenous Iron Over Nonsurgical Transfusions In Major Burns.

Anemia is a frequent condition in burn patients due to a mixture of blood loss and chronic inflammation. Transfusions increase the probability of serious infections and reduce overall survival, especially when unrelated to perioperative blood loss. Once the surgical phase in burn patients is completed, the role of parenteral iron administration in the reduction of subsequent transfusions is not well established. Burn patients subjected to at least two surgeries and presenting progressive anemia after concluding the surgical phase, without major symptoms, were selected (n=12). Those patients with confirmed iron deficiency were treated with intravenous (i.v.) ferric carboxymaltose (n=8). Subsequently, these patients were compared with a group of 18 control patients selected from our historical database (n=1375), matching controls by age (±5 years), sex, and TBSA burn (±6%). The objective was to verify if i.v. iron administration reduced the need for blood transfusions after the surgical phase. The analysis concluded that none of the cases treated required transfusions compared to 44% of the controls. There were no side effects related to the i.v. iron infusion. This result suggests that i.v. iron supplementation with ferric carboxymaltose could be an alternative in anemic patients without major symptoms once the surgical phase is completed. Iron deficiency should be assessed and i.v. supplementation must be administered if required in burn patients showing progressive anemia.

L'anémie, à la fois par pertes sanguines et inflammation, est fréquente chez les brûlés. Les transfusions, en particulier lorsque l'anémie n'est pas liée à la chirurgie, sont corrélées à la survenue d'infections sévères et à la mortalité. Une fois la phase chirurgicale terminée, le rôle de la thérapie martiale intraveineuse sur l'épargne transfusionnelle est mal connu. Nous avons évalué 12 patients brûlés, ayant été opérés au moins 2 fois et ne devant plus l'être, qui développaient une anémie progressive bien tolérée. Les 8 patients ayant une carence martiale ont reçu du carboxymaltose ferrique intraveineux. Ils ont été comparés avec 18 patients témoins, sélectionnés dans notre base de données de 1 375 dossiers, appariés sur l'âge +/- 5 ans, le sexe et la surface brûlée +/- 6%, l'objectif étant de vérifier si le traitement permettait effectivement de réduire les transfusions. Effectivement, aucun des patients traités n'a été transfusé, contre 44% des témoins. Aucun effet secondaire n'a été observé après administration de fer. Ceci suggère que des patients brûlés, chirurgie terminée, anémiques pauci- symptomatiques par carence martiale devraient recevoir un traitement martial IV.

Encefalopatía progresiva de origen carencial: identificar a los pacientes en riesgo de déficit de tiamina / Progressive encephalopathy associated with nutritional deficiencies: Identifying patients at high risk for developing thiamine deficiency

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Epidemiología y pronóstico tardío de la sepsis en ancianos / Epidemiology and long-term outcome of sepsis in elderly patients

OBJETIVOS: Examinar los datos epidemiológicos de pacientes sépticos mayores de 65 años con ingreso en UCI e identificar predictores de supervivencia a 2 años. DISEÑO: Estudio de cohortes prospectivo. PACIENTES: Criterios de sepsis al ingreso a UCI. Ámbito: UCI de 40 camas en un hospital terciario. RESULTADOS: El estudio incluyó a 237 pacientes ancianos (≥ 65 años de edad) y 281 controles (< 65 años), n = 518. Al menos una enfermedad subyacente estaba presente en el 70% de los pacientes ancianos en comparación con solo el 56,1% en controles (p < 0,01). Entre los mayores de 65 años se registró mayor prevalencia de enfermedades crónicas (diabetes, enfermedad obstructiva pulmonar crónica e insuficiencia cardíaca crónica), presentación más frecuente como shock séptico (52,3 vs. 42%; p < 0,05) y abdomen como foco (52 vs. 36%; p < 0,01). El 9% de los pacientes dados de alta hospitalaria falleció en el seguimiento posterior de 2 años, aumentando hasta el 20% en los ancianos. Los predictores independientes de mortalidad a 2 años en los pacientes ancianos fueron: insuficiencia cardíaca crónica (hazard ratio ajustada [aHR] 2,24; intervalo de confianza del 95% [IC 95%] 1,28-3,94; p < 0,01), insuficiencia renal aguda (aHR 3,64; IC 95% 2,10-6,23; p < 0,01), insuficiencia respiratoria aguda (aHR 3,67; IC 95%: 2,31-5,86; p < 0,01) y antibioterapia empírica inadecuada (aHR 2,19; IC 95% 1,32-3,62; p < 0,01).Conclusiones La sepsis en mayores de 65 años presenta diferencias relevantes en sus características demográficas y presentación clínica. Tras ajustar por potenciales factores de confusión, la terapia antimicrobiana empírica inadecuada se asoció con una reducción del doble en la supervivencia a los 2 años

OBJECTIVES: A study was made of the epidemiological data of sepsis requiring admission to the ICU in patients over 65 years of age, with an evaluation of independent predictors of survival at 2 years. DESIGN: A prospective cohort study was made. PATIENTS: Patients meeting criteria for sepsis upon admission to the ICU. SETTING: A 40-bed ICU in a tertiary hospital. RESULTS: The study group included 237 elderly patients (≥ 65 years of age) and 281 controls (< 65 years of age) (n = 518). At least one chronic comorbid condition was present in 70% of the elderly patients as compared to only 56.1% of patients under age 65 (P < .01). There were several epidemiological differences between the groups: the prevalence of chronic diseases (diabetes, chronic obstructive pulmonary disease, and chronic heart failure), presentation as septic shock (52.3% vs 42%; P < .05), and the abdomen as the source of sepsis (52% vs 36%; P < .01) were all more frequent in elderly patients. Nine percent of the global patients discharged from hospital died in the 2-year follow-up period, but this rate reached 20% among the elderly. Independent predictors of 2-year mortality in the elderly were: chronic heart failure (adjusted hazard ratio [aHR] 2.24, 95% confidence interval [CI 95%] 1.28-3.94; P < .01), acute renal failure (aHR 3.64, 95%CI 2.10-6.23; P < .01), acute respiratory failure (aHR 3.67, 95%CI 2.31-5.86; P < .01), and inappropriate empirical antimicrobial therapy (aHR 2.19, 95%CI 1.32-3.62; P < .01). CONCLUSIONS: Sepsis showed different demographic characteristics and clinical presentations in the elderly. In the aging cohort, after adjusting for potential confounders, inadequate empirical antimicrobial therapy was associated to a 2-fold decrease in survival at two years

[Epidemiology and long-term outcome of sepsis in elderly patients]. / Epidemiología y pronóstico tardío de la sepsis en ancianos.

OBJECTIVES: A study was made of the epidemiological data of sepsis requiring admission to the ICU in patients over 65 years of age, with an evaluation of independent predictors of survival at 2 years. DESIGN: A prospective cohort study was made. PATIENTS: Patients meeting criteria for sepsis upon admission to the ICU. SETTING: A 40-bed ICU in a tertiary hospital. RESULTS: The study group included 237 elderly patients (≥ 65 years of age) and 281 controls (<65 years of age) (n=518). At least one chronic comorbid condition was present in 70% of the elderly patients as compared to only 56.1% of patients under age 65 (P<.01). There were several epidemiological differences between the groups: the prevalence of chronic diseases (diabetes, chronic obstructive pulmonary disease, and chronic heart failure), presentation as septic shock (52.3% vs 42%; P<.05), and the abdomen as the source of sepsis (52% vs 36%; P<.01) were all more frequent in elderly patients. Nine percent of the global patients discharged from hospital died in the 2-year follow-up period, but this rate reached 20% among the elderly. Independent predictors of 2-year mortality in the elderly were: chronic heart failure (adjusted hazard ratio [aHR] 2.24, 95% confidence interval [CI 95%] 1.28-3.94; P<.01), acute renal failure (aHR 3.64, 95%CI 2.10-6.23; P<.01), acute respiratory failure (aHR 3.67, 95%CI 2.31-5.86; P<.01), and inappropriate empirical antimicrobial therapy (aHR 2.19, 95%CI 1.32-3.62; P<.01). CONCLUSIONS: Sepsis showed different demographic characteristics and clinical presentations in the elderly. In the aging cohort, after adjusting for potential confounders, inadequate empirical antimicrobial therapy was associated to a 2-fold decrease in survival at two years.

Prevalencia de procesos y patologías en la atención urgente hospitalaria / Prevalence of processes and pathologies in emergency hospital care

Objetivos. Estudiar las diferencias de comportamientoentre ingresos urgentes y programados en los procesosmás prevalentes y el resto en la casuística hospitalariaespañola y su relación con la edad de los pacientes,comparando los años 2002 y 2007.Métodos. Diseño observacional y descriptivo duranteesos años. Se clasifican los grupos relacionados de diagnóstico(GRD) en alta prevalencia (25 más frecuentes)y resto, se confeccionan cuatro subgrupos según ésta(alta o baja) e ingreso (electivo o no). Se analiza estanciamedia, peso relativo, número de diagnósticos y procedimientosy mortalidad en función de la edad, por mediodel test de Student y/o ANOVA, según proceda, para variablescuantitativas y el de χ2 de Pearson para cualitativas,comparando ambas según análisis de datos ya tabulados.Se asume significación estadística para p<0,05.Resultados. El subgrupo de alta prevalencia e ingresourgente presenta mayor edad, proporción de varones,estancia media, mortalidad, número de diagnósticosy procedimientos (todo con p<0,0001), tanto en 2002como en 2007. La gravedad, complejidad y consumode recursos –medidos con esas variables– alcanza sumáximo en las cohortes de 65-69 y 70-74 años, respectivamente,con ingreso urgente.Conclusiones. Existen claras diferencias entre los procesos,según su prevalencia y acceso, y debe priorizarseel conocimiento y la información de los más frecuentesy urgentes para mejorar la efectividad, la eficienciay la calidad(AU)

Objectives. To study the behavioural differences betweenscheduled and emergency admissions in the processesmost prevalent in Spanish hospitals and theirrelationship with the age of patients, comparing 2002and 2007.Methods. Observational and descriptive design forthose years. Diagnostic related groups (DRGs) wereclassified into high prevalence (the 25 most frequent)and the rest; four subgroups were prepared accordingto this (high or low) and admission (elective or not).Mean length of stay was analyzed, together with relativeweight, number of diagnoses and procedures andmortality by age, using the Student and/or ANOVA testsfor quantitative variables and Pearson’s χ2 qualitativecomparison of means and proportions for tabular data,assuming statistical significance at p <0.05.Results. The high prevalence and emergency admissionsubgroup has higher age, ratio of males, mean lengthof stay, mortality, number of diagnoses and procedures(all p <0.0001), in both 2002 and 2007. The complexityand resource consumption measured by such variablespeaks in the 65-69 and 70-74 cohorts respectively, withemergency admission.Conclusions. There are clear differences between theprocesses according to their prevalence and accessibility;priority must be given to knowledge and informationon the most frequent and urgent admissions toimprove the effectiveness, efficiency and quality(AU)

Infarto bulbar paramedial bilateral secundario a radioterapia / Bilateral paramedial bulbar infarction secondary to radiotherapy

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